Complement Membrane Attack Complex

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.

Also Known As:

Membrane Attack Complex; C 5b-9; C5b-8-poly-C9; C5b-9; Cytolytic Terminal Complement Complex; Terminal Complement Complex; C5b 8 poly C9; Complement Complex C5b 9; Complement Complex, Terminal; Complex, Terminal Complement; Complement Complex C5b-9

Pharmalogical Action Categories:

Immunologic Factors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement Membrane Attack Complex: 1025

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Disease

Drug/Important Bio-Agent (IBA)